Huntington's disease
For clinicians and researchers
Refine.med aims to provide clinician-facing evidence summaries that are tightly linked to living systematic reviews and a curated knowledge graph. This early preview focuses on layout and structure rather than full data.
The goal is to support, not replace, guideline-based care and clinical judgement. We aim to make it faster to see “what the totality of trials currently suggests” for a given question.
High-level evidence map
The same treatments-at-a-glance view available to patients can be toggled into a more technical mode that highlights effect sizes, confidence intervals, risk of bias, and population characteristics.
Placeholder: for now we show the simplified version used elsewhere on the site.
Treatments at a glance (preview)
- What this shows: How common options line up against broad outcome areas.
- What this is not: Personal medical advice; use it to guide questions with your care team.
- How to read it: Arrows for direction, strength badge for confidence, expand rows for the bottom line.
- ^ = likely improves
- +/- = mixed / depends
- = = no clear effect
- ? = not enough evidence
- Emerging to Moderate = more studies and confidence
- Limited = early or small data
| Intervention | Movement | Mood & behaviour | Thinking | Daily function | Quality of life |
|---|---|---|---|---|---|
Improves chorea Likely improvesModerate | Mood can shift Mixed / dependsLimited | No clear change No clear effectLimited | Mixed day-to-day Mixed / dependsLimited | Mixed impact Mixed / dependsLimited | |
Not for movement No clear effectLimited | Mood improves Likely improvesModerate | Mixed clarity Mixed / dependsLimited | May help routine Mixed / dependsLimited | Often better Likely improvesEmerging | |
Improves balance Likely improvesEmerging | Mood boost Likely improvesEmerging | Unclear Mixed / dependsLimited | Helps function Likely improvesEmerging | Overall better Likely improvesEmerging | |
Not for movement No clear effectLimited | Mood improves Likely improvesEmerging | Mixed Mixed / dependsLimited | Mixed support Mixed / dependsLimited | Often better Likely improvesEmerging |
Expand a row to see the bottom line and key points. Scroll horizontally if you need more room on smaller screens.
VMAT2 inhibitorMedicationOutcomes
Several trials suggest a meaningful reduction in chorea movements.
Some people report mood changes; monitoring is important.
Current studies have not shown a clear effect on thinking or memory.
Improvements in movement may translate into small changes in daily tasks.
Quality-of-life findings vary between studies.
Improves involuntary movements; monitor mood and side effects closely.
- Multiple trials show chorea improvement.
- Mood and behaviour shifts can occur; requires monitoring.
- Limited data on thinking and daily function.
AntidepressantMedicationOutcomes
Typically used for mood symptoms rather than movement.
Frequently used to treat depression and anxiety in HD.
Some people feel clearer, others notice little change.
Mood improvements can support day-to-day functioning.
Some studies suggest better overall wellbeing.
Good for mood symptoms; indirect benefits on daily life are possible.
- Commonly prescribed for depression/anxiety in HD.
- Monitor for activation or side effects.
- Movement effects are minimal.
Physiotherapy & exerciseRehabOutcomes
Exercise and movement training may help balance and confidence.
Staying active is often linked with better mood and energy.
Research is still developing for thinking skills.
Can support walking, transfers, and independence.
Many people report feeling better overall when active.
Low-risk way to support movement, mood, and daily confidence.
- Small but consistent improvements in balance and mobility.
- Often improves mood and energy.
- Programs vary; tailor to ability and safety needs.
Talking therapyTherapyOutcomes
Not aimed at movement symptoms.
Can help with coping, relationships, and emotional regulation.
May support planning and problem solving for daily life.
Skills from therapy can support routines and decision-making.
Many people value a regular space to talk and plan.
Supports coping and relationships; not targeted to movement symptoms.
- Helps emotional regulation and planning.
- Useful for patients and caregivers.
- May indirectly support routines and wellbeing.
Planned clinician tools
- Question-by-question evidence summaries with key numbers.
- Links to protocols and analysis code on OSF where available.
- Versioned update history so you can see when evidence has changed.
How to interpret this site
We recommend using Refine.med as an adjunct to local guidelines, shared decision-making conversations, and your own reading of the literature. If you notice any discrepancies or have suggestions, we expect to provide a feedback channel in later versions.
Placeholder: this section will later include contact details and a short methods summary tailored to clinicians.
For methods details, see the About / methods page.